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Active substance, group:
Udenafil (Udenafil), Erectile dysfunction treatment agent, PDE-5 inhibitor

Dosage form:
film coated tablets

Contraindications:
Hypersensitivity, simultaneous administration of nitrates and other nitric oxide donators, simultaneous use with other types of treatment of erectile dysfunction, age over 71 years, childhood and adolescence (up to 18 years).

Dosage and administration (instructions):
Inside, regardless of the meal, 30 minutes before
estimated sexual activity-100-200 mg of Zidena (taking into account individual effectiveness and tolerability). The maximum frequency of application-1 time per day.

Pharmacological action:
Means for the treatment of erectile dysfunction, selective reversible inhibitor of cyclic guanosine monophosphate specific type 5 PDE.
Enhances the relaxing effect of nitric oxide by inhibiting PDE-5, responsible for the breakdown of cyclic guanosine monophosphate in the cavernous body.
There is a relaxation of smooth muscles of the arteries, blood flow to the tissues of the penis, which causes an erection.

Side effect:
Frequency: very often (10% or more), often (1-10%), infrequently (0.1-1%).
CNS: infrequently-dizziness, headache, stiffness of the neck muscles, paresthesia.
From the sensory organs: often – redness of eyes; rarely, blurred vision, eye pain, increased lacrimation.
From the digestive system: often-dyspepsia, discomfort in the abdomen; infrequently-toothache, nausea, constipation, gastritis.
From the respiratory system: often-nasal congestion; infrequently-shortness of breath, dryness of the nasal mucosa.
From the skin: infrequently – swelling of the face (including eyelid), urticaria.
From the musculoskeletal system: infrequently-periarthritis.
Other: very often – < tides> of blood to the skin of the face; often – discomfort in the chest, a feeling of heat; infrequently-thirst, pain in the chest, abdomen, fatigue.
Side effects (post-marketing studies): palpitations, nosebleeds, tinnitus, diarrhea, allergic reactions (skin rash, erythema), prolonged erection, feeling of General discomfort, feeling cold, postural dizziness, cough.

Special instruction:
Sideney treatment of erectile dysfunction (including using udenafil) should not be used in diseases of the heart, in which sexual activity is not recommended.
Patients with aortic stenosis are sensitive to vasodilators (including PDE inhibitors).
In the event of an erection lasting more than 4 hours (regardless of the presence of pain), patients should seek medical help. In the absence of timely treatment, priapism can lead to damage to erectile tissue and erectile dysfunction.

Interaction:
Inhibitors of cytochrome P450 CYP3A4 isoenzymes (ketoconazole, Itraconazole, ritonavir, indinavir, cimetidine, erythromycin, grapefruit juice) can enhance the action of Zidena.
Ketoconazole (400 mg) increases bioavailability and Cmax Zidena (100 mg)
in 2 times and 0.8 times respectively.
Dexamethasone, rifampicin and antiepileptic drugs (carbamazepine, phenytoin, phenobarbital) accelerate the metabolism of the drug and weaken its effect.
At simultaneous reception with bmkk, alpha-blockers and anti-hypertensive drugs etc. can be observed additional reduction in systolic and diastolic blood pressure by 7-8 mmHg.art.
Zidena and drugs from the group of alpha-blockers with joint administration should be prescribed in minimal doses.