Fildena®

Fildena Fildena

Fildena is used to treat erectile dysfunction. The therapeutic effect of Fildena is aimed at promoting natural sexual arousal in men. The primary active ingredient in Fildena is sildenafil.

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  • Brand(s):Fildena
  • Manufacturer:Fortune Health Care
  • Disease(s):Erectile Dysfunction / Impotence / Pulmonary Arterial Hypertension
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Is Fildena XXX available in regular stores?

Fildena xxx is a drug for oral administration, intended for the treatment of erectile dysfunction. With sexual arousal, the drug restores reduced erectile function by increasing blood flow to the penis.

The physiological mechanism that leads to erection involves the release of nitric oxide (NO) in cavernous bodies during sexual arousal. The released nitric oxide activates the enzyme guanylate cyclase, which stimulates an increase in the level of cyclic guanosine monophosphate (cGMP), which in turn causes relaxation of the smooth muscles of the cavernous bodies, contributing to blood flow.

Why buy Fildena XXX

Sildenafil is a powerful and selective inhibitor of cGMP-specific phosphodiesterase 5 (FDE5) in cavernous bodies, where FDE5 is responsible for the breakdown of cGMP. The Fildena xxx effects of sildenafil on erection are peripheral. Sildenafil does not have a direct relaxing effect on isolated cavernous human bodies, but powerfully enhances the relaxing effect of NO on this tissue. When you activate a metabolic pathway NO/cGMP, what happens when sexual stimulation, inhibition sildenafilum leads to increased levels of cGMP in the cavernous bodies. Thus, in order for sildenafil to cause the necessary pharmacological effect, sexual arousal is necessary.

How should I take Fildena XXX

In vitro studies have shown the selectivity of the effect of sildenafil on PDE5, which is actively involved in the erection process. The effect of sildenafil on FDE5 is more powerful than on other known phosphodiesterases. This effect is 10 times more powerful than the effect on PDE6, involved in the processes of photopreformation in the retina. When using maximum recommended doses for sildenafil PDE5 selectivity to 80 times greater than its selectivity for times higher than Fildena xxx. In particular, the selectivity of sildenafil to PDE5 is 4000 times higher than its selectivity to PDE3-cGMP-specific isoform of phosphodiesterase involved in the regulation of cardiac contractility.

Description of Fildena XXX Tablets

There is evidence that special clinical studies have been conducted to assess the time during which sildenafil leads to erection in response to sexual stimulation. In clinical studies involving patients who used sildenafil on an empty stomach, during peoplesmart the median time to beginning of erection in patients who have achieved erections with rigidity of 60 % (sufficient to perform sexual intercourse) was 25 min (range 12-37 minutes). In another study using RigiScan, sildenafil was still able to induce an erection 4-5 hours after application.

How should I take Fildena XXX

Sildenafil causes a slight and short-term decrease in blood pressure, which in most cases has no clinical manifestations. The average maximum decrease in systolic blood pressure in the supine position after oral administration of sildenafil at a dose of 100 mg was 8.4 mm Hg. the Corresponding change in diastolic blood pressure in the supine position was 5.5 mm Hg. these reductions in blood pressure are well coordinated with the vasodilator action of sildenafil, possibly due to increased levels of cGMP in the smooth muscles of the vessels. Single oral administration of sildenafil at doses up to 100 mg in healthy volunteers did not cause any clinically significant changes in the electrocardiogram.

There are data from the study of hemodynamic effects due to a single oral administration of sildenafil at a dose of 100 mg in patients with severe coronary heart disease (with stenosis of less than one coronary artery more than 70 %): mean systolic and diastolic blood pressure at rest decreased by 7% and 6%, respectively, relative to the baseline. Mean pulmonary systolic pressure decreased by 9%. Sildenafil did not lead to a change in cardiac output and did not reduce blood flow through the stenotic coronary arteries.

Description of Fildena XXX Tablets

No clinically significant differences were demonstrated for the time prior to the occurrence of limiting angina when using sildenafil compared with placebo in studies using the exercise test involving patients with erectile dysfunction and chronic stable angina, who constantly used antianginal drugs (except nitrates).

Working of Fildena XXX Tablets

Easy and temporary violation of the ability to distinguish colors (blue/green) was detected in some patients, 1 hour after the application of sildenafil at a dose of 100 mg. These effects completely disappeared in 2 hours after drug administration. The possible mechanism of this change in color recognition is related to the inhibition of PDE6 involved in the phototransformation cascade of reactions in the retina. Sildenafil does not affect visual acuity or contrast sensitivity. In studies involving patients with documented macular dystrophy, the use of sildenafil (once at a dose of 100 mg) did not cause significant changes in the results of visual studies (visual acuity, Amsler grid, traffic light color recognition modeling, Humphrey perimeter and photostress).

Single oral administration of sildenafil at a dose of 100 mg by healthy volunteers did not affect sperm motility or morphology.

There are clinical studies of the use of sildenafil in patients aged 19 to 87 years. The following groups of patients were represented: elderly patients, patients with hypertension, patients with diabetes mellitus, coronary heart disease, hyperlipidemia, spinal cord injuries, depression, transurethral resection of the prostate, Radical prostatectomy. Groups of patients who were not sufficiently represented or included in clinical studies: patients after surgery on the pelvic organs, patients after radiation therapy, patients with severe renal or hepatic insufficiency and patients with some cardiovascular diseases.

In fixed-dose studies, the number of patients reporting improved erectile function was higher than in the placebo group. In controlled clinical studies, the number of cases of sildenafil withdrawal was low and similar to that in the placebo group.

Fildena XXX Tablets Dosage

In all these studies, patients reported improvement in the application of sildenafil with psychogenic erectile dysfunction mixed erectile dysfunction, organic erectile dysfunction, elderly patients, diabetes, coronary heart disease, hypertension, transurethral resection of the prostate, radical prostatectomy, spinal cord injury, depression. The safety and efficacy of sildenafil have been confirmed by these long-term studies.

Pharmacokinetics.

Absorption. Sildenafil is rapidly absorbed. The maximum plasma concentrations of the drug are reached within 30-120 minutes (with a median of 60 minutes) after its oral application on an empty stomach. The average absolute bioavailability after oral administration is 41 % (with a range of values from 25 to 63 %). In the recommended dose range (from 25 to 100 mg), the indicators of AUC and Cmax of sildenafil after oral administration are increased proportionally to the dose.

In the application of sildenafil during meals extent of absorption is reduced, with an average elongation Tmax of 60 min and an average decrease in Cmax of 29 %.

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Distribution. The average equilibrium volume of distribution (Vd) is 105 liters, which indicates the distribution of the drug in the tissues of the body. After a single oral administration of sildenafil at a dose of 100 mg, the average maximum total plasma concentration of sildenafil is approximately 440 ng / ml (coefficient of variation is 40 %). Since the binding of sildenafil and its main N-desmethyl metabolite to plasma proteins reaches 96 %, the average maximum plasma concentration of free sildenafil reaches 18 ng/ml (38 nmol). The degree of binding to plasma proteins does not depend on the total concentrations of sildenafil.

Fildena XXX Tablets Side Effects:

There is evidence that in healthy volunteers who used sildenafil once in a dose of 100 mg, after 90 minutes less than 0.0002 % (on average 188 ng) of the dose was determined in the ejaculate.

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Metabolism. The metabolism of sildenafil is carried out mainly with the participation of microsomal liver isoenzymes CYP3A4 (main pathway) and CYP2C9 (secondary pathway). The main circulating metabolite is formed by N-demethylation of sildenafil. The selectivity of the metabolite relative to PDE5 is comparable to the selectivity of sildenafil, and the activity of the metabolite relative to PDE5 is approximately 50% of the activity of the initial substance. The plasma concentration of this metabolite is approximately 40% of the concentration of sildenafil in plasma. The n-demethylated metabolite is further metabolized and its half-life is approximately 4 hours.

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