Fildena®

Fildena Fildena

Fildena is used to treat erectile dysfunction. The therapeutic effect of Fildena is aimed at promoting natural sexual arousal in men. The primary active ingredient in Fildena is sildenafil.

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  • Brand(s):Fildena
  • Manufacturer:Fortune Health Care
  • Disease(s):Erectile Dysfunction / Impotence / Pulmonary Arterial Hypertension
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What Is Fildena strong Tablets?

The drug Fildena strong used in erectile dysfunction. Selectively inhibits phosphodiesterase type 5 (PDE5), contained mainly in the smooth muscles of the cavernous body, and prevents the destruction of cGMP. The increase in the level of cGMP leads to a decrease in intracellular calcium concentration, followed by increased filling of the sinuses with blood against the background of an increase in arterial blood flow in the penis and compression of the excretory veins.
The drug increases the degree and increases the duration of erection, resulting from sexual stimulation. The effectiveness of the drug remains with long-term treatment (for 1 year).
Sildenafil inhibits ФДЭ6 of the retina (although weaker than, selectivity of 10:1) and can cause violations of color vision.

Drug Contraindications

Sildenafil increases antiplatelet and disaggregation effect of nitric oxide (II) and its donors, blocks the formation of blood clots ex vivo. When using the drug in high doses significantly increases bleeding time (no effect on blood clotting time).
A single dose above 30 mg is accompanied by an increase in plasma cGMP levels. Both arterial and venous vessels expand, causing a decrease in systolic and diastolic blood PRESSURE, an increase in heart rate.
It has an antidiuretic effect.
It does not affect reproductive function: the morphology, motility and viability of sperm, volume and viscosity of the ejaculate.
No teratogenic, mutagenic, clastogenic and carcinogenic properties were noted.

Fildena strong Usage Guidelines

Quickly and almost completely absorbed by ingestion on an empty stomach. Tmax in plasma is achieved in 0.5-2 hours. Absolute bioavailability is 41%. Intake of fatty foods reduces the degree of absorption and Fildena strong in the blood, increases Tmax in the blood for 1 hour.

How to Buy Fildena strong Online

Binding to plasma proteins-96%. Vd at steady state is 105 l, the average clearance of 41 l/h In the ejaculate through 1.5 h after administration of the drug sildenafil, and the concentration of the main metabolite (UK-103.320) are, respectively, 18% and 5% of its content in plasma. When using 3 for 9 days cumulation of the drug is 36%.

How to Use Fildena strong

The drug is subjected to presystemic metabolism and intensive biotransformation. The main circulating metabolite-UK-103.320-is formed during the” first passage ” through the liver as a result Of n-demethylation of sildenafil in the area of N-methylpiperazine. The metabolite has a similar effect to sildenafil, but it is inferior in activity by about 50%.

What is Fildena Fildena strong?

T1 / 2 is 4 h (varies from 2 to 8 h). Up to 80% of the metabolites of sildenafil excreted in the feces, 14% – urine (less than 4% in the form of UK-103.320).
Pharmacokinetics in special clinical cases
In elderly patients, reduced clearance, increased concentration of Fildena strong in blood plasma.
In patients with renal insufficiency Cmax value is 2 times higher than in healthy patients.
In patients with stable hepatic cirrhosis sildenafil clearance was reduced by 46%, Cmax was higher by 47%.

Is Fildena strong for women and children too?

Disorders of erection of organic, psychogenic and / or mixed etiology in patients:
– with diabetes;
— with obesity;
– after a radical prostatectomy — ;
– after a spinal cord injury.

How to take Fildena strong?

Viasil should be taken orally 1 hour before sexual intercourse. For most patients, the recommended dose is 50 mg. with insufficient efficacy against the background of good tolerability, the dose can be increased to 100 mg. The maximum recommended frequency of use is 1 time/
When using the drug in patients over the age of 65 years, patients with impaired liver function, severe renal failure, as well as while the use of inhibitors of CYP3A4 isoenzyme marked increase in the concentration of sildenafil in blood plasma. In this regard, it is possible to increase the effectiveness of the drug and increase the side effects of therapy. In such cases, it is necessary to assess the feasibility of the drug at a dose of 25 mg.

Fildena strong precautions

CNS: headache, dizziness, asthenia, insomnia.
From the cardiovascular system: shortness of breath, vasodilation (tides), hypotension, nasal congestion.
On the part of the senses: lacrimation, impaired light perception, impaired color perception, impaired clarity of vision, hearing loss up to its complete loss.
From the digestive system: dyspepsia, diarrhea, nausea, abdominal pain.
From the musculoskeletal system: lumbalgia, myalgia, muscle hypertonicity.
Other: skin rashes, predisposition to respiratory and urinary tract infections, prolonged painful erection.

Will I suffer from side effects when using Fildena strong?

– simultaneous treatment with nitrates;
– hypersensitivity to the components of the drug.
With caution, the drug should be prescribed for severe violations of liver and kidney function, anatomical deformities of the penis, multiple myeloma, hereditary pigment retinitis, gastric ulcer and duodenal ulcer in the acute phase, severe forms of hypertension, severe forms of arterial hypotension, in the presence of anamnestic indications for myocardial infarction and/or stroke in the previous 6 months, with life-threatening cardiac arrhythmias, unstable angina, as well as patients under the age of 18.

Fildena strong with Food and Alcohol.

Before taking the drug for the diagnosis of erectile dysfunction, determine its possible causes and the choice of adequate treatment should collect a complete medical history and conduct a thorough urological and General clinical examination, especially in patients with concomitant cardiovascular diseases, in which increased sexual activity is undesirable (including severe forms of coronary artery disease and hypertension).
Elderly patients are not recommended the appointment of high doses. Frequent (more than 1) use in high doses increases the risk of side effects. Patients with concomitant coronary artery disease are classified as high risk. Evaluation of the benefit / risk ratio is necessary for patients with heart failure, low BCC. With caution, the drug should be prescribed to patients with hypertension (AD 170/110 mm Hg. Hg) and hypotension (BP 90/50 mm Hg. art.) with extreme caution prescribe the drug to patients with concomitant hypertension, receiving multicomponent hypotensive drug therapy.
With caution, the drug should be prescribed to patients with diseases that have to develop priapism (including sickle cell anemia, multiple myeloma, leukemia).
It is not recommended to combine the use of Viasil with other drugs for the treatment of erectile dysfunction.
Use in Pediatrics
The drug is not intended for use in patients under the age of 18 years.

How long does it take for Fildena strong work?

Symptoms: sensation of heat, dizziness, facial flushing, headache, violation of definition of sight, dyspeptic phenomena, decrease in blood pressure.
Treatment: symptomatic therapy. Dialysis is ineffective.

What happens when nitrates combine with the drug?

Do not combine the drug with the treatment of nitrates (including nitroglycerin), molsidomine and other nitric oxide donators.
Viasil enhances orthostatic hypotension caused by nitroglycerin, as well as antiplatelet effects of sodium nitroprusside.
While the use of Veselom cimetidine, ketoconazole, Itraconazole, erythromycin, saquinavir, ritonavir and other drugs (CYP3A4 inhibitors) increase the concentration of sildenafil in plasma.
While the use of Veselom rifampicin and other inducers of CYP3A4 decrease the concentration of sildenafil in plasma.

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