Fildena®

Fildena Fildena

Fildena is used to treat erectile dysfunction. The therapeutic effect of Fildena is aimed at promoting natural sexual arousal in men. The primary active ingredient in Fildena is sildenafil.

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  • Brand(s):Fildena
  • Manufacturer:Fortune Health Care
  • Disease(s):Erectile Dysfunction / Impotence / Pulmonary Arterial Hypertension
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Fildna 50 Review and Description

The pharmacokinetics of sildenafil in the recommended dose range is linear. Absorption After ingestion of sildenafil is rapidly absorbed. Absolute bioavailability averages around 40% (25% to 63%). In vitro, sildenafil at a concentration of about 1.7 ng/ml (3.5 nm) inhibits human PDE5 activity by 50 %. After a single dose of sildenafil at a dose of 100 mg, the average maximum concentration of free sildenafil in the blood plasma (Cmax) of men is about 18 ng/ml (38 nm). Fildena 50 when taking sildenafil inside on an empty stomach is achieved on average for 90 minutes. When taken in combination with fatty foods, the rate of absorption decreases: Cmax decreases by an average of 29%, and the time to reach the maximum concentration (Tmax) increases by 60 minutes, but the degree of absorption does not significantly change (the area under the pharmacokinetic curve concentration-time (AUC) decreases by 11 %).

Fildena 50 Pricing and Dosage

Distribution the volume of distribution of sildenafil in the equilibrium state averages 105 l. the Relationship with plasma proteins of sildenafil and its main circulating n-demethyl metabolite is approximately 96% and does not depend on the total concentration of the drug. Less than 0.0002% of the dose (average 188 ng) were detected in semen after 90 min after administration of sildenafil. Metabolism sildenafil is metabolized mainly in the liver under the action of cytochrome CYP3A4 isoenzyme (main pathway) and cytochrome CYP2C9 isoenzyme (minor pathway). The main circulating active metabolite, formed as a result Of n-demethylation of sildenafil, undergoes further metabolism. The selectivity of the action of this metabolite against PDE is comparable to that of sildenafil, and its activity against PDE5 in vitro is about 50% of the activity of sildenafil. The concentration of metabolite in the blood plasma of healthy volunteers was about 40 % of the concentration of sildenafil. N-demethyl metabolite undergoes further metabolism; its half-life (T1 / 2) is about 4 hours. The total clearance of sildenafil is 41 l / h, and the final T1 / 2 – 3-5 hours. After oral administration, as well as after intravenous administration, sildenafil is excreted in the form of metabolites, mainly by the intestine (about 80% of the oral dose) and, to a lesser extent, by the kidneys (about 13% of the oral dose).

How to Buy Fildena 50 Online

Treatment of erection disorders characterized by inability to achieve or maintain penis erection sufficient for satisfactory sexual intercourse. Sildenafil is effective only in the presence of sexual stimulation.
Contraindications

What is Erectile Dysfunction?

Hypersensitivity to sildenafil or any other component of the drug. Use in patients receiving constant or intermittent nitric oxide donators, organic nitrates or nitrites in any form, as sildenafil enhances the hypotensive effect of nitrates (see section “Interaction with other drugs”). Use in patients for whom sexual activity is undesirable (for example, with severe cardiovascular diseases, such as severe heart failure, unstable angina). Hypotension (blood pressure less than 90/50 mm Hg. art.) Chronic renal failure of severe severity. Suffered in the last six months, a violation of cerebral circulation or myocardial infarction.

How Fildena CT 50mg treats erectile dysfunction problems?

Hereditary degenerative diseases of the retina, including retinitis pigmentosa. Lactose intolerance, lactase deficiency, glucose-galactose malabsorption. Simultaneous administration of ritonavir. The safety and efficacy of sildenafil in combination with other means of treatment of erection disorders have not been studied, so the use of such combinations is not recommended (see section “Special instructions”). According to the registered indication sildenafil is not intended for use in children under 18 years. According to the registered indication sildenafil is not intended for use in women

How to take Fildena CT 50mg?

The recommended dose for most adult patients is Fildena 50 about 1 hour before sexual activity. Taking into account the effectiveness and tolerability of the dose can be increased to 100 mg or reduced to 25 mg.The maximum recommended dose is 100 mg. The maximum recommended frequency of application – once a day. Renal dysfunction in mild to moderate renal failure (CC 30-80 ml/min) dose adjustment is not required. Since the excretion of sildenafil is disturbed in patients with liver damage (in particular, in cirrhosis), the dose of sildenafil should be reduced to 25 mg.

Why Fildena CT 50mg is a popular treatment for erectile dysfunction problems?

Combined use with other drugs in combination with ritonavir, the maximum single dose of sildenafil should not exceed 25 mg, and the frequency of application – 1 time in 48 hours (see section “Interaction with other drugs”). When combined with cytochrome CYP3A4 isoenzyme inhibitors (erythromycin, saquinavir, ketoconazole, Itraconazole), the initial dose of sildenafil should be 25 mg (see section “Interaction with other drugs”). To minimize the risk of postural hypotension in patients taking α-blockers, sildenafil should be started only after stabilization of hemodynamics in these patients. Consideration should also be given to reducing the initial dose of sildenafil (see para. sections “Special instructions”and” Interaction with other medicines”). Elderly patients adjustment of the dose of sildenafil is not required.

Can Fildena CT 50mg be taken on empty stomach?

Film coated tablets, 25 mg, 50 mg, 100 mg. 1, 2, 4, 7 or 10 tablets in a contour cell package of polyvinyl chloride film and aluminum foil printed lacquered. Fildena 50 tablets in cans of polyethylene terephthalate for medicines, capped with screw-on lids with the control of the first opening or the “push-turn” system made of polypropylene or polyethylene, or polymer banks made of polypropylene for medicines, capped with lids tensioned with the control of the first opening of polyethylene. One Bank or 1, 2, 3, 4, 5 or 6 contour cell packages together with the instruction on application place in cardboard packing (pack).

Fildena
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