Fildena®

Fildena Fildena

Fildena is used to treat erectile dysfunction. The therapeutic effect of Fildena is aimed at promoting natural sexual arousal in men. The primary active ingredient in Fildena is sildenafil.

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  • Brand(s):Fildena
  • Manufacturer:Fortune Health Care
  • Disease(s):Erectile Dysfunction / Impotence / Pulmonary Arterial Hypertension
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  • How Fildena treats erectile dysfunction problems?
  • Who can use Fildena?
  • Why Fildena is a popular treatment for erectile dysfunction problems?
  • Can Fildena 50mg be taken on empty stomach?
  • How to take Fildena?
  • Will I suffer from side effects when using Fildena?
  • How long does it take for Fildena work?
  • Is Fildena available in regular stores?
  • Fildena Tablets Dosage
  • Why buy Fildena
  • Description of Fildena Tablets
  • How Fildena treats erectile dysfunction problems?

    How Fildena treats erectile dysfunction problems?

    Of all the health problems that can unsettle a modern man, erectile dysfunction, which is often called impotence, stands out. The tragedy of this disease is that in society it is perceived as something shameful, so the patient in most cases remains alone with his trouble. Often men, faced with the inability to start or complete sexual intercourse, avoid even a visit to the doctor, hoping for help “miraculous” pharmacy, but as a result of such self-treatment only exacerbate their condition. Meanwhile, modern treatment of erectile dysfunction can return a man the joy of a full sexual life life, even in difficult cases. Erectile dysfunction-what is it? Erectile dysfunction involves chronic difficulties with the implementation of full sexual intercourse. It can be a question both of problems with an erection, and of absence of an ejaculation or an orgasm, and also of the other phenomena interfering to derive pleasure from sex and to satisfy the partner. However, more often patients come to the doctor with a complaint about the first version of the disorder — when sexual arousal penis for some reason is not filled with blood sufficiently (remains soft, does not increase in size).

    Who can use Fildena?

    Who can use Fildena?

    The new drug Viagra 100 (Fildena 100) contains 100 mg of sildenafil in one tablet — the most standard dosage for generics, the active ingredient of which is sildenafil. Feldene extra power is for those men who need increased dose of sildenafil, or for those who want to save — it is possible to break the tablet into 2 parts. Thus, the cost of one dose of the drug becomes significantly lower compared to the purchase of other generics of sildenafil. According to the effectiveness and safety of this drug is at the level of the best analogues — side effects are very rare and poorly expressed, and the effectiveness of improving potency is very high.

    the drug should be taken 45-60 minutes before sexual intercourse;
    duration-about 5 hours;
    the recommended dose is 1/2 tablet;
    maximum daily dose – 1 tablet;
    it is not recommended to combine with alcohol and fatty foods (this reduces the effectiveness of the drug).

    Fildena extra power will give you confidence in your sexual abilities in any situation.

    Why Fildena is a popular treatment for erectile dysfunction problems?

    Why Fildena is a popular treatment for erectile dysfunction problems?

    Risk factors for ED are similar to those for cardiovascular disease (e.g. physical inactivity, obesity, Smoking, hypercholesterolemia and metabolic syndrome), diabetes mellitus; some of them can be modified. In DM erectile dysfunction develops three times more often and 10-15 years earlier than in a relatively healthy population. The main reasons for the defeat prialnik arteries in diabetes — diabetic neuropathy and microangiopathy. Moreover, men with mild ED have risk factors similar to those for ED in General. Thus, light ED is an important indicator of the risk of associated underlying disease.

    Men complaining of mild ED should be appropriately examined (for the presence of predisposition to cardiovascular diseases). This fact was the reason for the active cooperation of urologists with therapists and cardiologists, using the first manifestation of ED as an indisputable proof of the need for a detailed cardiac examination.

    In the last 10 years, a theory has emerged that both CHD and ED are manifestations of endothelial insufficiency. Healthy endothelium has a number of different functions, but in the modern scientific literature endothelial dysfunction is understood as a violation of the balance between endothelial cells and vasodilators with a predominance of the latter. There is increasing evidence that ED may be an early manifestation of coronary heart disease and peripheral artery disease; thus, ED should not be considered only from the point of view of QoL, but also as a possible warning signal of the presence of cardiovascular disease.

    Can Fildena 50mg be taken on empty stomach?

    Can Fildena 50mg be taken on empty stomach?

    The implementation of the physiological mechanism of erection is associated with the release of nitric oxide (NO) in the cavernous body during sexual stimulation. This, in turn, leads to an increase in the level of cGMP, the subsequent relaxation of smooth muscle tissue of the cavernous body and an increase in blood flow.

    Sildenafil does not have a direct relaxing effect on the isolated cavernous human body, but enhances the effect of nitric oxide (NO) by inhibiting Fildena 100 mg, which is responsible for the breakdown of cGMP.

    Selective sildenafil against PDE5 in vitro, its activity against PDE5 superior activity against other known phosphodiesterase isoenzymes: more than 80 times – more than 700 times. Sildenafil 4000 times more selective towards PDE5 compared to, which is critical because is one of the key enzymes in the regulation of myocardial contractility.

    How to take Fildena?

    How to take Fildena?

    The use of sildenafil in doses up to 100 mg did not lead to clinically significant ECG changes in healthy volunteers. The maximum decrease in systolic pressure in the supine position after taking sildenafil at a dose of 100 mg was 8.3 mm Hg. art., and diastolic pressure by 5.3 mm Hg. more pronounced, but also transient effect on blood PRESSURE was observed in patients taking nitrates.

    In the study of the hemodynamic effect of sildenafil in a single dose of 100 mg in 14 patients with severe coronary artery disease (more than 70% of patients had stenosis of at least one coronary artery), systolic and diastolic resting pressure decreased by 7% and 6%, respectively, and pulmonary systolic pressure decreased by 9%. Sildenafil did not affect cardiac output and did not disturb blood flow in stenotic coronary arteries, and also led to an increase (by about 13%) in adenosine-induced coronary flow in both stenotic and intact coronary arteries.

    Fildena side effects

    Fildena side effects

    In a double-blind placebo-controlled study of 144 patients with erectile dysfunction and stable angina, taking antianginal drugs (except nitrates), physical exercises were performed until the severity of angina symptoms decreased. The duration of the exercise was significantly longer (19.9 seconds; 0.9-38.9 seconds) in patients taking sildenafil in a single dose of 100 mg compared to patients receiving placebo.

    Will I suffer from side effects when using Fildena?

    Will I suffer from side effects when using Fildena?

    In a randomized, double-blind, placebo-controlled study, the effect of sildenafil dose change (up to 100 mg) in men (n=568) with erectile dysfunction and hypertension taking more than two antihypertensive drugs was studied. Sildenafil improved erection in 71% of men compared to 18% in the placebo group. The frequency of adverse effects was comparable with that in other groups of patients, as well as in persons taking more than three antihypertensive drugs.

    How long does it take for Fildena work?

    How long does it take for Fildena work?

    In some patients, 1 h after taking sildenafil at a dose of 100 mg with the Farnsworth-Munsel test 100 revealed a slight and transient violation of the ability to distinguish shades of color (blue/green). After 2 hours after taking the drug, these changes were absent. It is believed that color vision impairment is caused by inhibition of PDE6, which is involved in the process of light transmission in the retina. Sildenafil had no effect on visual acuity, contrast perception, electroretinogram, intraocular pressure or pupil diameter.

    In a placebo-controlled cross-examination of patients with proven early age macular degeneration (n=9), sildenafil was well tolerated at a single dose of 100 mg. There were no clinically significant changes in vision assessed by special visual tests (visual acuity, Amsler lattice, color perception, color pass simulation, Humphrey perimeter, and photostress).

    Is Fildena available in regular stores?

    Is Fildena available in regular stores?

    The efficacy and safety of sildenafil were evaluated in 21 randomized double-blind placebo-controlled study lasting up to 6 months in 3000 patients aged 19 to 87 years, with erectile dysfunction of different etiology (organic, psychogenic or mixed). Efficacy of the drug was assessed globally using diary erections, international index of erectile function (validierung questionnaire on the state of sexual function) and polling partner.

    Fildena Tablets Dosage

    Fildena Tablets Dosage

    The efficacy of sildenafil, defined as the ability to achieve and maintain an erection sufficient for satisfactory sexual intercourse, has been demonstrated in all studies conducted and has been confirmed in long-term studies lasting 1 year. In studies with the use of fixed-dose proportion of patients reporting that treatment improved their erections were 62% (dose of sildenafil 25 mg), 74% (Fildena 100 mg) and 82% (dose sildenafil 100 mg) compared to 25% in the placebo group. Analysis of the international index of erectile function showed that in addition to improving the erection treatment with sildenafil also increased the quality of orgasm, allowing to achieve satisfaction from sexual intercourse and General satisfaction.

    According to the generalized data, 59% of patients with diabetes, 43% of patients who underwent radical prostatectomy and 83% of patients with spinal cord injuries (against 16%, 15% and 12% in the placebo group, respectively) were reported to have improved erection in the treatment with sildenafil.
    Pharmacokinetics
    The pharmacokinetics of sildenafil in the recommended dose range is linear.

    Why buy Fildena

    Why buy Fildena

    After intake of sildenafil is rapidly absorbed. Absolute bioavailability averages around 40% (25% to 63%). In vitro, sildenafil at a concentration of about 1.7 ng/ml (3.5 nm) inhibits human PDE5 activity by 50%. After a single dose of sildenafil at a dose of 100 mg, the average Cmax of free sildenafil in the blood plasma of men is about 18 ng / ml (38 nm). Cmax when taking sildenafil on an empty stomach is achieved for an average of 60 minutes (from 30 minutes to 120 minutes). When taken in combination with fatty food the rate of absorption is reduced: Cmax is reduced on average by 29%, and Dmah increased by 60 min, however, the extent of absorption was not significantly altered (AUC reduced by 11%).

    Description of Fildena Tablets

    Description of Fildena Tablets

    Sildenafil at steady state an average is 105 L. the Binding of sildenafil and its main circulating N-demethylase metabolite with blood plasma proteins is about 96% and does not depend on the total concentration of the drug. Less than 0.0002% of the dose of sildenafil (average 188 ng) was found in semen 90 minutes after administration of the drug.

    Fildena
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